Hydrochloric Acid → Hydrochloric Acid

HRID 2264890Notes

Reaction equation

HRID 2264890 reaction equation
C(OC([NH:8][CH2:9][CH2:10][C:11]([N:13]1[CH2:25][CH2:24][C:23]2[C:22]3[C:17](=[CH:18][CH:19]=[C:20]([CH2:26]C4C=CC=C(O)C=4)[CH:21]=3)[NH:16][C:15]=2[CH2:14]1)=[O:12])=O)(C)(C)C.[ClH:34].[O:35]1[CH2:40][CH2:39]OCC1>>[NH2:8][CH2:9][CH2:10][C:11]([N:13]1[CH2:25][CH2:24][C:23]2[C:22]3[C:17](=[CH:18][CH:19]=[C:20]([CH3:26])[CH:21]=3)[NH:16][C:15]=2[CH:14]1[C:15]1[CH:14]=[C:40]([OH:35])[CH:39]=[CH:22][CH:23]=1)=[O:12].[ClH:34]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 131728594HCID 131728594, compound

Product 2

HCID 313Hydrochloric AcidHCID 11772457HCID 11772457, compound

Procedure

(tert-Butoxy)-N-{3-[1-(3-hydroxyphenyl)-6-methyl-(1,2,3,4-tetrahydro-beta-carbolin-2-yl)]-3-oxopropyl}carboxamide was treated with HCl in dioxane (4 N, 10 equiv) for 30 min, and the solvent was removed to give 3-(2-beta-alanyl-6-methyl-2,3,4,9-tetrahydro-1H-beta-carbolin-1-yl)phenol 15 as its HCl salt.

Workup

  1. customthe solvent was removed

Sources & evidence

ORD record
ord-b3d74f01422e47a99cff75d02eb598e0
Source dataset
uspto-grants-2010_12
Patent number
US07855295B2

Reaction notes

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