Sodium Hydroxide → HCID 67212115, compound

HRID 2264901Notes

Reaction equation

HRID 2264901 reaction equation
[OH-].[Na+:2].C([O:5][C:6]([C:8]1[N:16]([CH3:17])[C:15]2[CH:14]=[CH:13][N:12]=[CH:11][C:10]=2[C:9]=1[NH:18][C:19]1[CH:24]=[CH:23][C:22]([I:25])=[CH:21][C:20]=1[F:26])=[O:7])C>>[Na+:2].[F:26][C:20]1[CH:21]=[C:22]([I:25])[CH:23]=[CH:24][C:19]=1[NH:18][C:9]1[C:10]2[CH:11]=[N:12][CH:13]=[CH:14][C:15]=2[N:16]([CH3:17])[C:8]=1[C:6]([O-:7])=[O:5]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 595965873-(2-Fluoro-4-iodo-phenylamino)-1-methyl-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid ethyl ester

Product 1

HCID 67212115HCID 67212115, compoundYield 111.4%

Conditions

Temperature
60 °C

Procedure

Sodium hydroxide (39 mg, 1.0 mmol) was added to a suspension of 3-(2-fluoro-4-iodo-phenylamino)-1-methyl-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid ethyl ester (400 mg, 0.91 mmol) in IMS (6 ml) and the reaction heated at 60° C. for 5 hours. The reaction mixture was concentrated in vacuo to yield the title compound as a yellow solid (439 mg, 100%). LCMS (method B): RT=2.19 min, M-Na+H+=412.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-1d1bcb8319dd412bb7ebb94fd7e8649b
Source dataset
uspto-grants-2010_12
Patent number
US07855216B2

Reaction notes

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