Hydroxyamine hydrochloride → 3-Pyridinecarboxaldehyde, 4,5-dichloro-, oxime

A solution of 4,5-dichloropyridine-3-carbaldehyde (8.01 g, 45.51 mmol) in ethanol (50 ml) was added to a rapidly stirred solution of hydroxylamine hydrochloride (3.48 g, 50.06 mmol) in water (50 ml). The reaction was stirred at room temperature for 45 min then partitioned between ethyl acetate (100 ml) and water (100 ml). The aqueous layer was extracted with ethyl acetate (2×50 ml) and the combined organic layers were dried over magnesium sulfate before being concentrated in vacuo to afford the title compound as a white solid (8.3 g, 96%).

1. customthen partitioned between ethyl acetate (100 ml) and water (100 ml)
2. extractionThe aqueous layer was extracted with ethyl acetate (2×50 ml)
3. dry with materialthe combined organic layers were dried over magnesium sulfate
4. concentrationbefore being concentrated in vacuo

ORD 기록

ord-4309f50acffc4223a5662a5548b23b67

출처 데이터셋

uspto-grants-2010_12

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US07855216B2