Hydrochloric Acid → HCID 44626933, compound

HRID 2265080Notes

Reaction equation

HRID 2265080 reaction equation
[ClH:1].[CH3:2][N:3]1[C:7]([C:8]2[O:12][CH:11]=[N:10][C:9]=2[CH3:13])=[N:6][N:5]=[C:4]1[S:14][CH2:15][CH2:16][CH2:17][N:18]1[CH2:23][C@H:22]2[C@:20]([C:24]3[CH:29]=[CH:28][C:27]([C:30]([F:33])([F:32])[F:31])=[CH:26][CH:25]=3)([CH2:21]2)[CH2:19]1>CCOCC>[ClH:1].[CH3:2][N:3]1[C:7]([C:8]2[O:12][CH:11]=[N:10][C:9]=2[CH3:13])=[N:6][N:5]=[C:4]1[S:14][CH2:15][CH2:16][CH2:17][N:18]1[CH2:23][C@H:22]2[C@:20]([C:24]3[CH:25]=[CH:26][C:27]([C:30]([F:31])([F:32])[F:33])=[CH:28][CH:29]=3)([CH2:21]2)[CH2:19]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 11225043HCID 11225043, compound

Product 1

HCID 44626933HCID 44626933, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Hydrochloric acid (1M solution in Et2O, 19.4 mL) was added dropwise under N2 to a solution of (1S,5R)-3-(3-{[4-methyl-5-(4-methyl-1,3-oxazol-5-yl)-4H-1,2,4-triazol-3-yl]thio}propyl)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hexane (Example 14, 9 g) in Et2O (anhydrous, 135 mL). The resulting suspension was allowed to stir at room temperature for 2 h. The solid was then filtered, washed with Et2O and dried in vacuo overnight to provide the title compound (8.9 g) as off white solid (y=92%).

Workup

  1. filtrationThe solid was then filtered
  2. washwashed with Et2O
  3. customdried in vacuo overnight

Sources & evidence

ORD record
ord-6fdc2464f0c54f73a929b0ef09d9ccef
Source dataset
uspto-grants-2010_12
Patent number
US07855298B2

Reaction notes

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