HCID 68486934, compound → HCID 25258034, compound

HRID 2265088Notes

Reaction equation

HRID 2265088 reaction equation
[CH3:1][Si:2]([CH3:28])([CH3:27])[C:3]1[CH:4]=[C:5]([CH:20]=[C:21]([Si:23]([CH3:26])([CH3:25])[CH3:24])[CH:22]=1)[C:6]([NH:8][C:9]1[CH:19]=[CH:18][C:12]([CH:13]=[CH:14][C:15]([OH:17])=[O:16])=[CH:11][CH:10]=1)=[O:7].[H][H]>CO.[C].[Pd]>[CH3:26][Si:23]([CH3:24])([CH3:25])[C:21]1[CH:20]=[C:5]([CH:4]=[C:3]([Si:2]([CH3:28])([CH3:27])[CH3:1])[CH:22]=1)[C:6]([NH:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:13][CH2:14][C:15]([OH:17])=[O:16])=[CH:18][CH:19]=1)=[O:7]

Participants

5

Reactant 2

HCID 68486934HCID 68486934, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 25258034HCID 25258034, compoundYield 80%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

Compound 3 (10 mg) was dissolved in methanol (1 ml), and a catalytic amount of palladium carbon was added thereto. The obtained mixture was stirred in a hydrogen atmosphere at room temperature for 5 hours. After the reaction was over, the reaction mixture was filtered through Celite, and the filtrate was purified by silica gel column chromatography to obtain Compound 4 (8 mg, 80%) as a white solid.

Workup

  1. filtrationwas filtered through Celite
  2. customthe filtrate was purified by silica gel column chromatography

Sources & evidence

ORD record
ord-51c19b2a81de4c8a92cbe70b9b8e7947
Source dataset
uspto-grants-2010_12
Patent number
US07855300B2

Reaction notes

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