反应详情

Compound 17a (293 mg) was dissolved in toluene (8.34 ml), and Lawesson's reagent (189 mg) was added thereto in a nitrogen atmosphere. The obtained mixture was stirred while refluxing under heating for 2 hours. The solvent was distilled off, and the residue was purified by neutral silica gel column chromatography (10% ethyl acetate/n-hexane) to obtain Compound 17b (319 mg, 76%) as a yellow foam material.

1. temperaturewhile refluxing
2. temperatureunder heating for 2 hours
3. distillationThe solvent was distilled off
4. customthe residue was purified by neutral silica gel column chromatography (10% ethyl acetate/n-hexane)