Lawesson's reagent → Ethyl 4-[[3,5-bis(trimethylsilyl)benzenecarbothioyl]amino]cinnamate

Participants

Reaction Steps

Compound 17a (293 mg) was dissolved in toluene (8.34 ml), and Lawesson's reagent (189 mg) was added thereto in a nitrogen atmosphere. The obtained mixture was stirred while refluxing under heating for 2 hours. The solvent was distilled off, and the residue was purified by neutral silica gel column chromatography (10% ethyl acetate/n-hexane) to obtain Compound 17b (319 mg, 76%) as a yellow foam material.

Provenance & Evidence