HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lawesson's reagent → (E)-Ethyl 3-[6-[[3,5-bis(trimethylsilyl)benzenecarbothioyl]amino]pyridin-3-yl]acrylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lawesson's reagent | HCID 87949 | — |
| Reactant | (E)-Ethyl 3-[6-[[3,5-bis(trimethylsilyl)benzoyl]amino]pyridin-3-yl]acrylate | HCID 86644273 | — |
| Reactant | Ethyl 4-[[3,5-bis(trimethylsilyl)benzenecarbothioyl]amino]cinnamate | HCID 86644287 | — |
| Product | (E)-Ethyl 3-[6-[[3,5-bis(trimethylsilyl)benzenecarbothioyl]amino]pyridin-3-yl]acrylate | HCID 86644288 | 92.6% |
Reaction Steps
Using Compound 18a (135 mg) and Lawesson's reagent (86.7 mg), Compound 18b (90.7 mg, 65%) was obtained as a yellow solid in the same manner as Compound 17b was synthesized.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07855300B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-ac54bc79ab454b0891e405f8a3689c7c |
| Source note | uspto-grants-2010_12 |