Diethylamine → HCID 68427031, compound

HRID 2265153Notes

Reaction equation

HRID 2265153 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH2:10][CH2:11][N:12](C(OC(C)(C)C)=O)[CH2:13][CH:14]=1.C(NCC)C.CCCCCC.C([OH:35])C>>[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C@H:9]1[CH2:10][CH2:11][NH:12][CH2:13][C@@H:14]1[OH:35]

Participants

4

Reactant 3

HCID 8021DiethylamineHCID 21879635Ethanol hexaneHCID 23157130HCID 23157130, compound

Product 1

HCID 68427031HCID 68427031, compound

Procedure

3.62 g of the entitled compound was obtained as a pale orange solid from the latter fraction (retention time: 14.8 min) in the same method as in Production Example 25-3, for which, however, tert-butyl 4-(2-chloro-4-fluorophenyl)-3,6-dihydro-2H-pyridine-1-carboxylate was used in place of tert-butyl 4-(2-chlorophenyl)-3,6-dihydro-2H-pyridine-1-carboxylate used in Production Example 25-3, and an optically-active column (Daicel's CHRALPAK AD column, 2 cm×25 cm; 0.1% diethylamine, hexane/ethanol=9/1; flow rate, 20 mL/min) was sued for the optical resolution.

Sources & evidence

ORD record
ord-f96e7948f5574e0996dc63e24d0e2e35
Source dataset
uspto-grants-2010_12
Patent number
US07855294B2

Reaction notes

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