2,6-Difluorobenzenesulfonyl chloride → 2-[[(2,6-difluorophenyl)sulfonyl]amino]-4-iodoBenzoic acid

HRID 2265206Notes

Reaction equation

HRID 2265206 reaction equation
[NH2:1][C:2]1[CH:10]=[C:9]([I:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[F:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[C:14]=1[S:20](Cl)(=[O:22])=[O:21]>>[F:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[C:14]=1[S:20]([NH:1][C:2]1[CH:10]=[C:9]([I:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5])(=[O:22])=[O:21]

Participants

3

Reactant 2

HCID 27342712,6-Difluorobenzenesulfonyl chlorideHCID 227247802-Amino-4-iodo-benzoic acid

Product 1

HCID 687736512-[[(2,6-difluorophenyl)sulfonyl]amino]-4-iodoBenzoic acid

Procedure

2-Amino-4-iodo-benzoic acid was sulfonylated with 2,6-difluorobenzenesulfonyl chloride as in EXAMPLE 1, Part A. 1H NMR (500 MHz, CD3OD): 8.05 (d, J=1.6, 1H), 7.72 (d, J=8.4, 1H), 7.68-7.60 (m, 1H), 7.48 (dd, J=8.4, 1.6, 1H), 7.16-7.09 (m, 2H).

Sources & evidence

ORD record
ord-e07034c3393449919f673547fbbf5525
Source dataset
uspto-grants-2010_12
Patent number
US07855292B2

Reaction notes

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