2,6-Difluorobenzenesulfonyl chloride → HCID 68768495, compound

HRID 2265215Notes

Reaction equation

HRID 2265215 reaction equation
[NH2:1][C:2]1[CH:11]=[C:10]([Br:12])[CH:9]=[CH:8][C:3]=1[C:4]([O:6]C)=[O:5].[F:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([F:20])[C:15]=1[S:21](Cl)(=[O:23])=[O:22]>>[F:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([F:20])[C:15]=1[S:21]([NH:1][C:2]1[CH:11]=[C:10]([Br:12])[CH:9]=[CH:8][C:3]=1[C:4]([OH:6])=[O:5])(=[O:23])=[O:22]

Participants

3

Reactant 2

HCID 27342712,6-Difluorobenzenesulfonyl chlorideHCID 17871390Methyl 2-Amino-4-bromobenzoate

Product 1

HCID 68768495HCID 68768495, compound

Procedure

Methyl 2-amino-4-bromobenzoate was sulfonylated with 2,6-difluorobenzenesulfonyl chloride and hydrolyzed as in EXAMPLE 1, Part B. 1H NMR (400 MHz, acetone-d6): 11.65 (s, 1H), 8.02 (d, J=8.5, 1H), 7.93 (d, J=1.8, 1H), 7.74-7.82 (m, 1H), 7.38 (dd, J=8.5, 1.9, 1H), 7.28-7.23 (m, 2H).

Sources & evidence

ORD record
ord-27edef2e8f514dcfa23747d3c0ff74eb
Source dataset
uspto-grants-2010_12
Patent number
US07855292B2

Reaction notes

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