2-(5-Hydroxy-4'-trifluoromethyl-biphenyl-3-yl)-4-methyl-pentanoic acid methyl ester → HCID 57754935, compound

HRID 226531Notes

Reaction equation

HRID 226531 reaction equation
[CH3:1][O:2][C:3](=[O:26])[CH:4]([C:9]1[CH:10]=[C:11]([C:16]2[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][CH:17]=2)[CH:12]=[C:13]([OH:15])[CH:14]=1)[CH2:5][CH:6]([CH3:8])[CH3:7].B(O)O.[F:30][C:31]1[CH:32]=[CH:33][CH:34]=[C:35]([C:37]([F:40])([F:39])[F:38])[CH:36]=1>>[CH3:1][O:2][C:3](=[O:26])[CH:4]([C:9]1[CH:10]=[C:11]([C:16]2[CH:17]=[CH:18][C:19]([C:22]([F:23])([F:25])[F:24])=[CH:20][CH:21]=2)[CH:12]=[C:13]([O:15][C:33]2[CH:34]=[C:35]([C:37]([F:39])([F:38])[F:40])[CH:36]=[C:31]([F:30])[CH:32]=2)[CH:14]=1)[CH2:5][CH:6]([CH3:8])[CH3:7]

Participants

3

Reactant 2

HCID 577549412-(5-Hydroxy-4'-trifluoromethyl-biphenyl-3-yl)-4-methyl-pentanoic acid methyl esterHCID 178505688HCID 178505688, compound

Product 1

HCID 57754935HCID 57754935, compoundYield 10%

Procedure

The title compound was prepared in 10% yield from 2-(5-hydroxy-4′-trifluoromethyl-biphenyl-3-yl)-4-methyl-pentanoic acid methyl ester (prepared in Example 15, step (f)) and 3-fluoro,5-trifluoromethylbenzene boronic acid under the conditions described in Example 15, step (g).

Sources & evidence

ORD record
ord-9a047b47fe834646bdec78d64420d2e5
Source dataset
uspto-grants-2009_07
Patent number
US07557244B2

Reaction notes

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