2,4-Dimethoxyaniline → 4-benzyloxy-N-(2,4-dimethoxyphenyl)indan-1-carboxamide

HRID 2265322Notes

Reaction equation

HRID 2265322 reaction equation
[CH2:1]([O:8][C:9]1[CH:17]=[CH:16][CH:15]=[C:14]2[C:10]=1[CH2:11][CH2:12][CH:13]2[C:18]([OH:20])=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:21][O:22][C:23]1[CH:29]=[C:28]([O:30][CH3:31])[CH:27]=[CH:26][C:24]=1[NH2:25]>>[CH2:1]([O:8][C:9]1[CH:17]=[CH:16][CH:15]=[C:14]2[C:10]=1[CH2:11][CH2:12][CH:13]2[C:18]([NH:25][C:24]1[CH:26]=[CH:27][C:28]([O:30][CH3:31])=[CH:29][C:23]=1[O:22][CH3:21])=[O:20])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 176522,4-DimethoxyanilineHCID 178544584-Benzyloxyindan-1-carboxylic acid

Product 1

HCID 178541644-benzyloxy-N-(2,4-dimethoxyphenyl)indan-1-carboxamideYield 79.8%

Procedure

By the reaction and treatment in the same manner as in Preparation Example 18 using 4-benzyloxyindan-1-carboxylic acid (0.8 g) and 2,4-dimethoxyaniline (0.5 g) as starting materials, 4-benzyloxy-N-(2,4-dimethoxyphenyl) indan-1-carboxamide (0.96 g) was obtained. melting point: 129.7° C.

Workup

  1. customBy the reaction and treatment in the same manner

Sources & evidence

ORD record
ord-728ff2aa0c8c4f43981701047de1efeb
Source dataset
uspto-grants-2010_12
Patent number
US07855297B2

Reaction notes

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