(3,5-Difluorophenyl)boronic acid → 2-[5-(3,5-Difluoro-phenoxy)-3',5'-bis-trifluoromethyl-biphenyl-3-yl]-4-methyl-pentanoic acid methyl ester

HRID 226537Notes

Reaction equation

HRID 226537 reaction equation
[CH3:1][O:2][C:3](=[O:40])[CH:4]([C:9]1[CH:10]=[C:11]([C:26]2[CH:31]=[C:30]([C:32]([F:35])([F:34])[F:33])[CH:29]=[C:28]([C:36]([F:39])([F:38])[F:37])[CH:27]=2)[CH:12]=[C:13]([O:15]C2C=CC=C(C(F)(F)F)C=2)[CH:14]=1)[CH2:5][CH:6]([CH3:8])[CH3:7].[F:41][C:42]1[CH:43]=[C:44](B(O)O)[CH:45]=[C:46]([F:48])[CH:47]=1>>[CH3:1][O:2][C:3](=[O:40])[CH:4]([C:9]1[CH:10]=[C:11]([C:26]2[CH:31]=[C:30]([C:32]([F:34])([F:33])[F:35])[CH:29]=[C:28]([C:36]([F:37])([F:38])[F:39])[CH:27]=2)[CH:12]=[C:13]([O:15][C:44]2[CH:43]=[C:42]([F:41])[CH:47]=[C:46]([F:48])[CH:45]=2)[CH:14]=1)[CH2:5][CH:6]([CH3:8])[CH3:7]

Participants

3

Reactant 2

HCID 2734338(3,5-Difluorophenyl)boronic acidHCID 57754998HCID 57754998, compound

Product 1

HCID 577549152-[5-(3,5-Difluoro-phenoxy)-3',5'-bis-trifluoromethyl-biphenyl-3-yl]-4-methyl-pentanoic acid methyl esterYield 15%

Procedure

The title compound was prepared in 15% yield from 2-[3′,5′-bis-trifluoromethyl-5-(3-trifluoromethyl-phenoxy)-biphenyl-3-yl]-4-methyl-pentanoic acid methyl ester (prepared in Example C) and 3,5-difluoro-phenylboronic acid under the conditions described in Example 15, step (g).

Sources & evidence

ORD record
ord-3f61d3dc7f844549ba0abf927d1fd43c
Source dataset
uspto-grants-2009_07
Patent number
US07557244B2

Reaction notes

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