HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3,5-Difluorophenyl)boronic acid → 2-[5-(3,5-Difluoro-phenoxy)-3',5'-bis-trifluoromethyl-biphenyl-3-yl]-4-methyl-pentanoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3,5-Difluorophenyl)boronic acid | HCID 2734338 | — |
| Reactant | HCID 57754998 | HCID 57754998 | — |
| Product | 2-[5-(3,5-Difluoro-phenoxy)-3',5'-bis-trifluoromethyl-biphenyl-3-yl]-4-methyl-pentanoic acid methyl ester | HCID 57754915 | 15% |
Reaction Steps
The title compound was prepared in 15% yield from 2-[3′,5′-bis-trifluoromethyl-5-(3-trifluoromethyl-phenoxy)-biphenyl-3-yl]-4-methyl-pentanoic acid methyl ester (prepared in Example C) and 3,5-difluoro-phenylboronic acid under the conditions described in Example 15, step (g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07557244B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-3f61d3dc7f844549ba0abf927d1fd43c |
| Source note | uspto-grants-2009_07 |