1,2,3,4-Tetrahydro-1-naphthoic acid → N-[(5-ethylthiophen-2-yl) methyl]-N-(4-isopropylphenyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide

HRID 2265429Notes

Reaction equation

HRID 2265429 reaction equation
[CH:1]1([C:11]([OH:13])=O)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1.[CH2:14]([C:16]1[S:20][C:19]([CH2:21][NH:22][C:23]2[CH:28]=[CH:27][C:26]([CH:29]([CH3:31])[CH3:30])=[CH:25][CH:24]=2)=[CH:18][CH:17]=1)[CH3:15]>>[CH2:14]([C:16]1[S:20][C:19]([CH2:21][N:22]([C:23]2[CH:24]=[CH:25][C:26]([CH:29]([CH3:30])[CH3:31])=[CH:27][CH:28]=2)[C:11]([CH:1]2[C:10]3[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=3)[CH2:4][CH2:3][CH2:2]2)=[O:13])=[CH:18][CH:17]=1)[CH3:15]

Participants

3

Reactant 2

HCID 125981461,2,3,4-Tetrahydro-1-naphthoic acidHCID 29282954[(5-Ethylthiophen-2-yl)methyl](4-isopropylphenyl)amine

Product 1

HCID 16679662N-[(5-ethylthiophen-2-yl) methyl]-N-(4-isopropylphenyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamideYield 10.9%

Procedure

By the reaction and treatment in the same manner as in Example 12 using 1,2,3,4-tetrahydronaphthalene-1-carboxylic acid (0.7 g) and [(5-ethylthiophen-2-yl)methyl](4-isopropylphenyl)amine (1.04 g) as starting materials, N-[(5-ethylthiophen-2-yl) methyl]-N-(4-isopropylphenyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide (0.18 g) was obtained.

Sources & evidence

ORD record
ord-b6edba0d841e4e5f9de71c61c45af780
Source dataset
uspto-grants-2010_12
Patent number
US07855297B2

Reaction notes

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