Benzenamine, 3,5-bis(trifluoromethyl)- → 2-[5'-Fluoro-5-(3,5-bis-trifluoromethyl-phenylamino)-3'-trifluoromethyl-biphenyl-3-yl]-4-methyl-pentanoic acid methyl ester

HRID 226544Notes

Reaction equation

HRID 226544 reaction equation
[CH3:1][O:2][C:3](=[O:34])[CH:4]([C:9]1[CH:10]=[C:11]([C:23]2[CH:28]=[C:27]([C:29]([F:32])([F:31])[F:30])[CH:26]=[C:25]([F:33])[CH:24]=2)[CH:12]=[C:13](OS(C(F)(F)F)(=O)=O)[CH:14]=1)[CH2:5][CH:6]([CH3:8])[CH3:7].[F:35][C:36]([F:49])([F:48])[C:37]1[CH:38]=[C:39]([CH:41]=[C:42]([C:44]([F:47])([F:46])[F:45])[CH:43]=1)[NH2:40]>>[CH3:1][O:2][C:3](=[O:34])[CH:4]([C:9]1[CH:10]=[C:11]([C:23]2[CH:24]=[C:25]([F:33])[CH:26]=[C:27]([C:29]([F:31])([F:30])[F:32])[CH:28]=2)[CH:12]=[C:13]([NH:40][C:39]2[CH:41]=[C:42]([C:44]([F:45])([F:46])[F:47])[CH:43]=[C:37]([C:36]([F:35])([F:48])[F:49])[CH:38]=2)[CH:14]=1)[CH2:5][CH:6]([CH3:8])[CH3:7]

Participants

3

Reactant 2

HCID 9480Benzenamine, 3,5-bis(trifluoromethyl)-HCID 577549252-(3'-Fluoro-5-trifluoromethanesulfonyloxy-5'-trifluoromethyl-biphenyl-3-yl)-4-methyl-pentanoic acid methyl ester

Product 1

HCID 577549182-[5'-Fluoro-5-(3,5-bis-trifluoromethyl-phenylamino)-3'-trifluoromethyl-biphenyl-3-yl]-4-methyl-pentanoic acid methyl esterYield 97%

Procedure

The title compound was prepared in 97% yield from 2-(5′-fluoro-5-trifluoromethanesulfonyloxy-3′-trifluoromethyl-biphenyl-3-yl)-4-methyl-pentanoic acid methyl ester (prepared in Example 40, step (a)) and 3,5-bis-(trifluoromethyl)aniline under the conditions described in Example 37, step (b).

Sources & evidence

ORD record
ord-9bf79fc9a4314e6ebf3010b0a6aa0095
Source dataset
uspto-grants-2009_07
Patent number
US07557244B2

Reaction notes

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