Benzenamine, 3,5-bis(trifluoromethyl)- → 2-[5'-Fluoro-5-(3,5-bis-trifluoromethyl-phenylamino)-3'-trifluoromethyl-biphenyl-3-yl]-4-methyl-pentanoic acid methyl ester

Participants

Role	Name	HCID	Charge
Reactant	Benzenamine, 3,5-bis(trifluoromethyl)-	HCID 9480	—
Reactant	2-(3'-Fluoro-5-trifluoromethanesulfonyloxy-5'-trifluoromethyl-biphenyl-3-yl)-4-methyl-pentanoic acid methyl ester	HCID 57754925	—
Product	2-[5'-Fluoro-5-(3,5-bis-trifluoromethyl-phenylamino)-3'-trifluoromethyl-biphenyl-3-yl]-4-methyl-pentanoic acid methyl ester	HCID 57754918	97%

Reaction Steps

The title compound was prepared in 97% yield from 2-(5′-fluoro-5-trifluoromethanesulfonyloxy-3′-trifluoromethyl-biphenyl-3-yl)-4-methyl-pentanoic acid methyl ester (prepared in Example 40, step (a)) and 3,5-bis-(trifluoromethyl)aniline under the conditions described in Example 37, step (b).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07557244B2
Source dataset	uspto-grants-2009_07
ORD ID	ord-9bf79fc9a4314e6ebf3010b0a6aa0095
Source note	uspto-grants-2009_07