反应详情

N-{4-[(2-Aminopyridin-4-yl)oxy]-3-fluorophenyl}-N′-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (250 mg) was dissolved in tetrahydrofuran (6.0 ml) under a nitrogen atmosphere, and triethylamine (0.247 ml) and phenyl chloroformate (0.163 ml) were added dropwise in this order at room temperature, followed by stirring for 30 min. The reaction mixture was stirred after addition of ethyl acetate and water. The organic layer was separated, washed with a 1N aqueous solution of sodium hydroxide, water and brine in this order, and dried over anhydrous sodium sulfate. The solvent was concentrated under reduced pressure. The residue was dissolved in N,N-dimethylformamide (6.0 ml). Triethylamine (0.822 ml) and 3-hydroxyazetidine hydrochloride (259 mg) were added at room temperature, followed by stirring overnight. The reaction mixture was partitioned between ethyl acetate and water. The organic layer was washed with a 1N aqueous solution of sodium hydroxide, water and brine in this order, and dried over anhydrous sodium sulfate. The solvent was concentrated under reduced pressure. The resultant residue was purified by silica gel column chromatography (eluent; ethyl acetate, ethyl acetate:methanol=95:5, 9:1). Fractions containing the target compound were concentrated under reduced pressure. To the resultant residue was added tert-butyl methyl ether:heptane=1:2 to precipitate a solid. The solid was collected by filtration and dried under aeration to provide the titled compound as white powder (173.7 mg, 56%).

1. stirringThe reaction mixture was stirred
2. customThe organic layer was separated
3. washwashed with a 1N aqueous solution of sodium hydroxide, water and brine in this order
4. dry with materialdried over anhydrous sodium sulfate
5. concentrationThe solvent was concentrated under reduced pressure
6. dissolutionThe residue was dissolved in N,N-dimethylformamide (6.0 ml)
7. additionTriethylamine (0.822 ml) and 3-hydroxyazetidine hydrochloride (259 mg) were added at room temperature
8. stirringby stirring overnight
9. customThe reaction mixture was partitioned between ethyl acetate and water
10. washThe organic layer was washed with a 1N aqueous solution of sodium hydroxide, water and brine in this order
11. dry with materialdried over anhydrous sodium sulfate
12. concentrationThe solvent was concentrated under reduced pressure
13. customThe resultant residue was purified by silica gel column chromatography (eluent; ethyl acetate, ethyl acetate:methanol=95:5, 9:1)
14. additionFractions containing the target compound
15. concentrationwere concentrated under reduced pressure
16. additionTo the resultant residue was added tert-butyl methyl ether
17. customheptane=1:2 to precipitate a solid
18. filtrationThe solid was collected by filtration
19. customdried under aeration