反应详情

温度

50 °C

N-(2-Fluoro-4-{[2-({[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl}amino)pyridin-4-yl]oxy}phenyl)-N′-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (63.4 mg) was suspended in ethanol (1.168 ml). To this was added a 1M solution of L-(+)-tartaric acid in ethanol (0.100 ml), followed by heating at 50° C. Water (0.1268 ml) was added thereto to dissolve completely. The reaction mixture was stirred at 50° C. for 1 hr and 45 min, then stirred overnight while allowing it to gradually cool down to room temperature. Insoluble matter was collected by filtration and washed with ethanol (0.200 ml). This was dried under aeration at room temperature to provide the titled compound as colorless crystals (66.7 mg, 85.1%).

1. dissolutionto dissolve completely
2. stirringstirred overnight
3. temperatureto gradually cool down to room temperature
4. filtrationInsoluble matter was collected by filtration
5. washwashed with ethanol (0.200 ml)
6. customThis was dried under aeration at room temperature