HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2265793Generated: October 30, 2026
Triphenylphosphine → 4-Bromo-2-(bromomethyl)-1-chlorobenzene
https://huagongshe.com/reaction/2265793
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | (5-Bromo-2-chlorophenyl)methanol | HCID 5074766 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-Bromo-2-(bromomethyl)-1-chlorobenzene | HCID 11558280 | — |
Reaction Steps
N-bromosuccinimide (4.0 g) is slowly added to a solution of 4-bromo-1-chloro-2-hydroxymethyl-benzene (5.0 g) and triphenylphosphine (5.9 g) in tetrahydrofuran (50 mL) chilled to 5° C. After 1 h stirring at ambient temperature the precipitate is filtered off, and the solvent is removed in vacuo. The residue is purified by chromatography on silica gel (cyclohexane/ethyl acetate 50:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07858587B2 |
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| Source dataset | uspto-grants-2010_12 |
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| ORD ID | ord-3d437a870e774826996f0513a7db314b |
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| Source note | uspto-grants-2010_12 |
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