Thionyl Chloride → 4-Bromo-1-chloro-2-(chloromethyl)benzene

HRID 2265794Notes

Reaction equation

HRID 2265794 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[C:4]([CH2:9]O)[CH:3]=1.S(Cl)([Cl:13])=O>ClCCl>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[C:4]([CH2:9][Cl:13])[CH:3]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 5074766(5-Bromo-2-chlorophenyl)methanol

Product 1

HCID 433790704-Bromo-1-chloro-2-(chloromethyl)benzene

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 4-bromo-1-chloro-2-hydroxymethyl-benzene (40.0 g) and thionyl chloride (60 mL) in dichloromethane (150 mL) is stirred at 45-50° C. for 5 h. Then the solvent and the excess reagent is removed in vacuo.

Workup

  1. customThen the solvent and the excess reagent is removed in vacuo

Sources & evidence

ORD record
ord-634b9fe7937d48c49f48cb0e27cac218
Source dataset
uspto-grants-2010_12
Patent number
US07858587B2

Reaction notes

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