反应详情

To a mixture of phenol (7.1 g) and potassium carbonate (11.1 g) in ethanol (100 mL) is added 4-bromo-2-bromomethyl-1-chloro-benzene (19.5 g). The mixture is stirred at ambient temperature over night. The ethanol is evaporated, and water is added to the residue. The resulting mixture is extracted with ethyl acetate, the combined extracts are dried over sodium sulfate, and the solvent is removed. The residue is purified by chromatography on silica gel (cyclohexane/ethyl acetate 70:30).

1. customThe ethanol is evaporated
2. additionwater is added to the residue
3. extractionThe resulting mixture is extracted with ethyl acetate
4. dry with materialthe combined extracts are dried over sodium sulfate
5. customthe solvent is removed
6. customThe residue is purified by chromatography on silica gel (cyclohexane/ethyl acetate 70:30)