Piperidin-4-ol → HCID 178515206, compound

HRID 2265836Notes

Reaction equation

HRID 2265836 reaction equation
[C:1]1([N:7]2[C:25](=[O:26])[C:10]3=[CH:11][NH:12][C:13]4[CH:14]=[CH:15][C:16]([N:19]5[CH2:24][CH2:23]N[CH2:21][CH2:20]5)=[N:17][C:18]=4[C:9]3=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH:27][CH:28]1CCNCC1>>[OH:27][CH:28]1[CH2:21][CH2:20][N:19]([C:16]2[CH:15]=[CH:14][C:13]3[NH:12][CH:11]=[C:10]4[C:25](=[O:26])[N:7]([C:1]5[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=5)[N:8]=[C:9]4[C:18]=3[N:17]=2)[CH2:24][CH2:23]1

Participants

3

Reactant 2

HCID 79341Piperidin-4-olHCID 178515211HCID 178515211, compound

Product 1

HCID 178515206HCID 178515206, compound

Procedure

The title compound was prepared following the procedure described for 6a using 4-hydroxypiperidine instead of piperazine. 1H-NMR (DMSO-d6) δ (ppm): 1.39 (2H, brm), 1.83 (2H, brm), 3.15 (1H, d, J=5.22 Hz), 3.71 (1H, m), 4.19 (2H, m), 4.74 (1H, d, J=4.40 Hz), 7.16 (1H, tt, J=7.40, 1.10 Hz), 7.21 (1H, d, J=9.34 Hz), 7.42 (2H, m), 7.78 (1H, d, J=9.34 Hz), 8.21 (2H, ddd, J=7.69, 1.92, 1.10 Hz), 8.52 (1H, s). m/z 362.4 (MH+).

Sources & evidence

ORD record
ord-a3e3fa61fbdd4a74af909755b3b8c664
Source dataset
uspto-grants-2010_12
Patent number
US07858614B2

Reaction notes

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