2-Methylpiperazine → HCID 178429872, compound

HRID 2265837Notes

Reaction equation

HRID 2265837 reaction equation
[C:1]1([N:7]2[C:25](=[O:26])[C:10]3=[CH:11][NH:12][C:13]4[CH:14]=[CH:15][C:16]([N:19]5[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]5)=[N:17][C:18]=4[C:9]3=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:27]C1CNCCN1>>[CH3:27][CH:23]1[NH:22][CH2:21][CH2:20][N:19]([C:16]2[CH:15]=[CH:14][C:13]3[NH:12][CH:11]=[C:10]4[C:25](=[O:26])[N:7]([C:1]5[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=5)[N:8]=[C:9]4[C:18]=3[N:17]=2)[CH2:24]1

Participants

3

Reactant 2

HCID 660572-MethylpiperazineHCID 178515211HCID 178515211, compound

Product 1

HCID 178429872HCID 178429872, compound

Procedure

The title compound was prepared following the procedure described for 6a using 2-methylpiperazine instead of piperazine. 1H-NMR (DMSO-d6) δ (ppm): 1.00 (3H, s), 2.78 (4H, brm), 3.05 (1H, m), 4.30 (2H, m), 7.07 (2H, m), 7.39 (2H, dd, J=8.24, 7.97 Hz), 7.75 (1H, d, J=9.34 Hz), 8.27 (2H, dd, J=7.42, 1.10 Hz), 8.37 (1H, s). m/z 361.4 (MH+).

Sources & evidence

ORD record
ord-386ea1459bf54923b9e92b85111de085
Source dataset
uspto-grants-2010_12
Patent number
US07858614B2

Reaction notes

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