3-Hydroxypiperidine → HCID 178515204, compound

HRID 2265838Notes

Reaction equation

HRID 2265838 reaction equation
[C:1]1([N:7]2[C:25](=[O:26])[C:10]3=[CH:11][NH:12][C:13]4[CH:14]=[CH:15][C:16](N5CCNCC5)=[N:17][C:18]=4[C:9]3=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH:27][CH:28]1[CH2:33][CH2:32][CH2:31][NH:30][CH2:29]1>>[OH:27][CH:28]1[CH2:33][CH2:32][CH2:31][N:30]([C:16]2[CH:15]=[CH:14][C:13]3[NH:12][CH:11]=[C:10]4[C:25](=[O:26])[N:7]([C:1]5[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=5)[N:8]=[C:9]4[C:18]=3[N:17]=2)[CH2:29]1

Participants

3

Reactant 2

HCID 232933-HydroxypiperidineHCID 178515211HCID 178515211, compound

Product 1

HCID 178515204HCID 178515204, compound

Procedure

The title compound was prepared following the procedure described for 6a using 3-hydroxypiperidine instead of piperazine. 1H-NMR (DMSO-d6) δ (ppm): 1.40 (2H, m), 1.75 (1H, m), 1.80 (1H, m), 2.92 (1H, dd, J=12.64, 8.79 Hz), 3.51 (1H, m), 4.10 (1H, m), 4.33 (1H, dd, J=12.63, 3.84 Hz), 4.91 (1H, d, J=4.40 Hz), 7.15 (1H, tt, J=7.42, 1.09 Hz), 7.20 (1H, d, J=9.34 Hz), 7.42 (2H, dd, J=8.52, 7.42 Hz), 7.80 (1H, d, J=9.34 Hz), 8.21 (2H, dd, J=8.79, 1.38 Hz), 8.53 (1H, s). m/z 361.4 (MH+).

Sources & evidence

ORD record
ord-db03eed03d85486493b4eee5ae960436
Source dataset
uspto-grants-2010_12
Patent number
US07858614B2

Reaction notes

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