1-(4-Fluorophenyl)piperazine → HCID 178515208, compound

HRID 2265839Notes

Reaction equation

HRID 2265839 reaction equation
[C:1]1([N:7]2[C:25](=[O:26])[C:10]3=[CH:11][NH:12][C:13]4[CH:14]=[CH:15][C:16]([N:19]5[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]5)=[N:17][C:18]=4[C:9]3=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[F:27][C:28]1[CH:33]=[CH:32][C:31](N2CCNCC2)=[CH:30][CH:29]=1>>[F:27][C:28]1[CH:33]=[CH:32][C:31]([N:22]2[CH2:21][CH2:20][N:19]([C:16]3[CH:15]=[CH:14][C:13]4[NH:12][CH:11]=[C:10]5[C:25](=[O:26])[N:7]([C:1]6[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=6)[N:8]=[C:9]5[C:18]=4[N:17]=3)[CH2:24][CH2:23]2)=[CH:30][CH:29]=1

Participants

3

Reactant 2

HCID 752601-(4-Fluorophenyl)piperazineHCID 178515211HCID 178515211, compound

Product 1

HCID 178515208HCID 178515208, compound

Procedure

The title compound was prepared following the procedure described for 6a using 1-(4-fluorophenyl)-piperazine instead of piperazine. 1H-NMR (DMSO-d6) δ (ppm): 3.22 (4H, brm), 3.83 (4H, brm), 7.07 (5H, m), 7.32 (1H, d, J=9.34 Hz), 7.43 (2H, dd, J=8.24, 7.69 Hz), 7.85 (1H, d, J=9.34 Hz), 8.19 (2H, dd, J=8.24, 0.82 Hz), 8.57 (1H, s). m/z 441.5 (MH+).

Sources & evidence

ORD record
ord-9e97229d6e07404ea31b53a25361c4c8
Source dataset
uspto-grants-2010_12
Patent number
US07858614B2

Reaction notes

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