2,6-Dimethylmorpholine → HCID 178429871, compound

HRID 2265845Notes

Reaction equation

HRID 2265845 reaction equation
[C:1]1([N:7]2[C:25](=[O:26])[C:10]3=[CH:11][NH:12][C:13]4[CH:14]=[CH:15][C:16](N5CCNCC5)=[N:17][C:18]=4[C:9]3=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:27][CH:28]1[O:33][CH:32]([CH3:34])[CH2:31][NH:30][CH2:29]1>>[CH3:34][CH:32]1[O:33][CH:28]([CH3:27])[CH2:29][N:30]([C:16]2[CH:15]=[CH:14][C:13]3[NH:12][CH:11]=[C:10]4[C:25](=[O:26])[N:7]([C:1]5[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=5)[N:8]=[C:9]4[C:18]=3[N:17]=2)[CH2:31]1

Participants

3

Reactant 2

HCID 1108622,6-DimethylmorpholineHCID 178515211HCID 178515211, compound

Product 1

HCID 178429871HCID 178429871, compound

Procedure

The title compound was prepared following the procedure described for 6a using 2,6-dimethylmorpholine instead of piperazine. 1H-NMR (DMSO-d6) δ (ppm): 1.19 (6H, d, J=7.05 Hz), 2.36 (2H, t, J=12.09, 10.98 Hz), 3.75 (4H, brm), 7.16 (1H, tt, J=7.42, 1.09 Hz), 7.43 (4H, m), 7.56 (2H, d, J=9.06 Hz), 8.23 (2H, dt, J=8.79, 1.37 Hz), 8.56 (1H, s). m/z 376.5 (MH+).

Sources & evidence

ORD record
ord-d01aa7cd0e024f95848c5c6e705283b4
Source dataset
uspto-grants-2010_12
Patent number
US07858614B2

Reaction notes

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