Piperazine → HCID 178515214, compound

HRID 2265847Notes

Reaction equation

HRID 2265847 reaction equation
C1(N2C(=O)C3=CNC4C=CC(N5CCNCC5)=NC=4C3=N2)C=CC=CC=1.F[C:28]1[CH:37]=[CH:36][C:35]2[NH:34][CH:33]=[C:32]3[C:38](=[O:47])[N:39]([C:41]4[CH:46]=[CH:45][CH:44]=[CH:43][N:42]=4)[N:40]=[C:31]3[C:30]=2[N:29]=1.[NH:48]1[CH2:53][CH2:52][O:51][CH2:50][CH2:49]1.N1CCNCC1>>[N:48]1([C:28]2[CH:37]=[CH:36][C:35]3[NH:34][CH:33]=[C:32]4[C:38](=[O:47])[N:39]([C:41]5[CH:46]=[CH:45][CH:44]=[CH:43][N:42]=5)[N:40]=[C:31]4[C:30]=3[N:29]=2)[CH2:53][CH2:52][O:51][CH2:50][CH2:49]1

Participants

5

Reactant 4

HCID 4837PiperazineHCID 8083MorpholineHCID 178515200HCID 178515200, compoundHCID 178515211HCID 178515211, compound

Product 1

HCID 178515214HCID 178515214, compound

Procedure

The title compound was prepared following the procedure described for 6a using 5b and morpholine instead of 5a and piperazine respectively. 1H-NMR (DMSO-d6) δ (ppm): 3.63 (4H, br), 3.72 (4H, br), 7.19 (2H, m), 7.82 (2H, m), 8.22 (1H, d, J=8.24 Hz), 8.48 (1H, dd, J=2.20, 1.10 Hz), 8.56 (1H, s). m/z 349.4 (MH+).

Sources & evidence

ORD record
ord-4d5feda435034f809e5fd5ff58ea8ca0
Source dataset
uspto-grants-2010_12
Patent number
US07858614B2

Reaction notes

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