Methyl 6-hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylate--hydrogen chloride (1/1) → HCID 68680121, compound

HRID 2265885Notes

Reaction equation

HRID 2265885 reaction equation
[CH3:1][O:2][C:3]1[CH:19]=[CH:18][C:6]([O:7][C:8]2[CH:13]=[CH:12][C:11]([S:14](Cl)(=[O:16])=[O:15])=[CH:10][CH:9]=2)=[CH:5][CH:4]=1.Cl.[OH:21][C:22]1[CH:23]=[C:24]2[C:29](=[CH:30][CH:31]=1)[CH:28]([C:32]([O:34][CH3:35])=[O:33])[NH:27][CH2:26][CH2:25]2.FC1C=CC(OC2C=CC(S(N3CCC4C(=CC=C(O)C=4)C3C(OC)=O)(=O)=O)=CC=2)=CC=1>>[OH:21][C:22]1[CH:23]=[C:24]2[C:29](=[CH:30][CH:31]=1)[CH:28]([C:32]([O:34][CH3:35])=[O:33])[N:27]([S:14]([C:11]1[CH:12]=[CH:13][C:8]([O:7][C:6]3[CH:18]=[CH:19][C:3]([O:2][CH3:1])=[CH:4][CH:5]=3)=[CH:9][CH:10]=1)(=[O:16])=[O:15])[CH2:26][CH2:25]2

Participants

4

Reactant 3

HCID 2759853Methyl 6-hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylate--hydrogen chloride (1/1)HCID 36783104-(4-methoxyphenoxy)benzenesulfonyl ChlorideHCID 68679822Methyl 2-[4-(4-fluorophenoxy)benzenesulfonyl]-6-hydroxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylate

Product 1

HCID 68680121HCID 68680121, compound

Procedure

4-(4-Methoxyphenoxy)benzenesulfonyl chloride is reacted with methyl 6-hydroxytetra-hydroisoquinoline-1-carboxylate hydrochloride in analogy to the method described in 3B to give the desired sulfonamide.

Sources & evidence

ORD record
ord-1755fc582b5642cd95401bcede94adef
Source dataset
uspto-grants-2010_12
Patent number
US07858619B2

Reaction notes

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