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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2265885Generated: October 31, 2026

Methyl 6-hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylate--hydrogen chloride (1/1) → HCID 68680121, compound

https://huagongshe.com/reaction/2265885

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 6-hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylate--hydrogen chloride (1/1)HCID 2759853—
Reactant4-(4-methoxyphenoxy)benzenesulfonyl ChlorideHCID 3678310—
ReactantMethyl 2-[4-(4-fluorophenoxy)benzenesulfonyl]-6-hydroxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylateHCID 68679822—
ProductHCID 68680121HCID 68680121—

Reaction Steps

4-(4-Methoxyphenoxy)benzenesulfonyl chloride is reacted with methyl 6-hydroxytetra-hydroisoquinoline-1-carboxylate hydrochloride in analogy to the method described in 3B to give the desired sulfonamide.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07858619B2
Source datasetuspto-grants-2010_12
ORD IDord-1755fc582b5642cd95401bcede94adef
Source noteuspto-grants-2010_12