4-Toluenesulfonyl chloride → HCID 6465104, compound

HRID 2265897Notes

Reaction equation

HRID 2265897 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][CH:9]=[CH:8][C:4]=1[CH2:5][CH2:6][NH2:7].[C:12]1([CH3:22])[CH:17]=[CH:16][C:15]([S:18](Cl)(=[O:20])=[O:19])=[CH:14][CH:13]=1.FC1C=CC(OC2C=CC(S(NCCC3C=CC=CC=3OC)(=O)=O)=CC=2)=CC=1>>[CH3:1][O:2][C:3]1[CH:11]=[CH:10][CH:9]=[CH:8][C:4]=1[CH2:5][CH2:6][NH:7][S:18]([C:15]1[CH:16]=[CH:17][C:12]([CH3:22])=[CH:13][CH:14]=1)(=[O:20])=[O:19]

Participants

4

Reactant 3

HCID 73974-Toluenesulfonyl chlorideHCID 748962-MethoxyphenethylamineHCID 66879518HCID 66879518, compound

Product 1

HCID 6465104HCID 6465104, compound

Procedure

5.0 g (33 mmol) of ortho-methoxyphenethylamine are reacted with 1.2 equivalents of para-toluenesulfonyl chloride in analogy to the method described under 19A, resulting in the title compound in virtually quantitative yield.

Sources & evidence

ORD record
ord-22811aff0852423ea40c54d766446bce
Source dataset
uspto-grants-2010_12
Patent number
US07858619B2

Reaction notes

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