Risedronate → Risedronate Sodium

HRID 2265924Notes

Reaction equation

HRID 2265924 reaction equation
[CH:1]1[CH:6]=[N:5][CH:4]=[C:3]([CH2:7][C:8]([P:14]([OH:17])([OH:16])=[O:15])([P:10]([OH:13])([OH:12])=[O:11])[OH:9])[CH:2]=1.C([O-])([O-])=O.[Na+:22].[Na+]>O>[CH:1]1[CH:6]=[N:5][CH:4]=[C:3]([CH2:7][C:8]([P:10]([O-:12])([OH:13])=[O:11])([P:14]([OH:17])([OH:16])=[O:15])[OH:9])[CH:2]=1.[Na+:22]

Participants

4

Reactant 2

HCID 5245RisedronateHCID 10340Sodium Carbonate

Product 1

HCID 4194514Risedronate SodiumYield 173.7%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

18.0 g of risedronic acid and 730 ml of deionized water are charged into a 1-liter reactor, equipped with mechanical stirrer and thermometer. The suspension, under stirring, is added with 3.4 g of Na2CO3. The admixture is kept under stirring for 30′, up to complete dissolution of the undissolved solids. The solution, whose pH is 4.57, is filtered on a paper filter and put into Lioguard chambers. The chambers are introduced into a lyophilizer and processed according to example 1. At the end 17 g of lyophilized amorphous sodium risedronate are thus obtained (yields 87.6%).

Workup

  1. customequipped with mechanical stirrer
  2. stirringunder stirring for 30′, up
  3. dissolutiondissolution of the undissolved solids
  4. filtrationThe solution, whose pH is 4.57, is filtered on a paper
  5. filtrationfilter
  6. additionThe chambers are introduced into a lyophilizer

Sources & evidence

ORD record
ord-6ec97298afa24f21a9fb8be2704b4ac6
Source dataset
uspto-grants-2010_12
Patent number
US07858634B2

Reaction notes

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