Risedronate → Risedronate Sodium

Participants

Reaction Steps

18.0 g of risedronic acid and 730 ml of deionized water are charged into a 1-liter reactor, equipped with mechanical stirrer and thermometer. The suspension, under stirring, is added with 3.4 g of Na2CO3. The admixture is kept under stirring for 30′, up to complete dissolution of the undissolved solids. The solution, whose pH is 4.57, is filtered on a paper filter and put into Lioguard chambers. The chambers are introduced into a lyophilizer and processed according to example 1. At the end 17 g of lyophilized amorphous sodium risedronate are thus obtained (yields 87.6%).

Provenance & Evidence