2-Pyridinecarboxaldehyde → HCID 22223215, compound

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Reaction Steps

The Scheme 3 shows a proposed process for synthesizing pyridinyl acrylic amide (16) with t-butyl group. Substituted pyridinecarboxaldehyde with t-butyl group (12) is prepared by reduction followed by radical substitution method (J. Heterocyclic Chem., 1989, 25, 45-48). Substituted nicotinic ester (10) is converted to corresponding pyridine-3-methanol (11). Pyridinyl-3-methanol is reacted with pivalic acid and silver nitrate to give pyridinecarboxaldehyde (12) via Tada's radical substitution. Compound (14) is synthesized from compound (12) with similar method of scheme 2. 4-t-Butylpyridinyl acrylic acid (14) is reacted with compound (15) to yield compound (16).

Provenance & Evidence