2-Chloronicotinic acid → Nicotinic Acid

HRID 2265927Notes

Reaction equation

HRID 2265927 reaction equation
N1C=CC=CC=1C(=C)C(N)=O.Cl[C:13]1[N:21]=[CH:20][CH:19]=[CH:18][C:14]=1[C:15]([OH:17])=[O:16]>>[C:15]([OH:17])(=[O:16])[C:14]1[CH:18]=[CH:19][CH:20]=[N:21][CH:13]=1

Participants

3

Reactant 2

HCID 762582-Chloronicotinic acidHCID 22223215HCID 22223215, compound

Product 1

HCID 938Nicotinic Acid

Procedure

The Scheme 14 shows a proposed process for synthesizing pyridinyl acrylamide (64). 2-Chloro-nicotinic acid compound (23) is reacted with various amines to yield nicotinic acid compound (60) with 2-alkylamino, 2-dialkylamino, 2-arylamino, or 2-N-alkyl-N-aryl-amino group, which undergoes similar reactions to scheme 5 to give pyridinyl acrylic acid (63). Pyridinyl acrylamide (64) is then obtained by the reaction of pyridinyl acrylic acid (63) with the amine compound (1).

Sources & evidence

ORD record
ord-eec683d2044848a8b81079ff7c407d44
Source dataset
uspto-grants-2010_12
Patent number
US07858621B2

Reaction notes

Loading…