2-Chloronicotinic acid → Nicotinic Acid

Participants

Reaction Steps

The Scheme 14 shows a proposed process for synthesizing pyridinyl acrylamide (64). 2-Chloro-nicotinic acid compound (23) is reacted with various amines to yield nicotinic acid compound (60) with 2-alkylamino, 2-dialkylamino, 2-arylamino, or 2-N-alkyl-N-aryl-amino group, which undergoes similar reactions to scheme 5 to give pyridinyl acrylic acid (63). Pyridinyl acrylamide (64) is then obtained by the reaction of pyridinyl acrylic acid (63) with the amine compound (1).

Provenance & Evidence