HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 2-(6-tert-Butyl-pyridin-3-yloxy)-N-(3-fluoro-4-methane sulfonylamino-benzyl)-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | N-[4-(aminomethyl)-2-fluorophenyl]methanesulfonamide hydrochloride | HCID 21097525 | — |
| Reactant | (6-Tert-butyl-pyridin-3-yloxy)-acetic acid | HCID 68786941 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-(6-tert-Butyl-pyridin-3-yloxy)-N-(3-fluoro-4-methane sulfonylamino-benzyl)-acetamide | HCID 59598296 | 65% |
Reaction Steps
3-Fluoro-4-methanesulfonylaminobenzylamine hydrochloride (158 mg, 0.62 mmol) was reacted with (6-tert-butyl-pyridin-3-yloxy)-acetic acid (130 mg) DMTMM (1.2 eq, 206 mg) and NEt3(2.5 eq, 220 μl) in THF to give the title compound (165 mg, 65%) after purification by column chromatography (Hex/EtOAc=1/3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07858621B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-c7f9340e73f643a69530fbfc68244673 |
| Source note | uspto-grants-2010_12 |