N-[4-(aminomethyl)-2-fluorophenyl]methanesulfonamide hydrochloride → HCID 59598182, compound

HRID 2265947Notes

Reaction equation

HRID 2265947 reaction equation
Cl.[NH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([NH:10][S:11]([CH3:14])(=[O:13])=[O:12])=[C:6]([F:15])[CH:5]=1.[F:16][C:17]([F:30])([F:29])[C:18]1[N:23]=[CH:22][C:21]([O:24][CH2:25][C:26](O)=[O:27])=[CH:20][CH:19]=1>>[F:15][C:6]1[CH:5]=[C:4]([CH:9]=[CH:8][C:7]=1[NH:10][S:11]([CH3:14])(=[O:13])=[O:12])[CH2:3][NH:2][C:26](=[O:27])[CH2:25][O:24][C:21]1[CH:22]=[N:23][C:18]([C:17]([F:16])([F:29])[F:30])=[CH:19][CH:20]=1

Participants

3

Reactant 2

HCID 21097525N-[4-(aminomethyl)-2-fluorophenyl]methanesulfonamide hydrochlorideHCID 666651231005171-56-1

Product 1

HCID 59598182HCID 59598182, compoundYield 88%

Procedure

N-(4-Aminomethyl-2-fluoro-phenyl)-methanesulfonamide HCl salt (270 mg, 1.00 mmol) was reacted with (6-trifluoromethyl-pyridin-3-yloxy)-acetic acid (221 mg) to give N-(3-fluoro-4-methanesulfonylamino-benzyl)-2-(6-trifluoromethyl-pyridin-3-yloxy)-acetamide (54 mg, 88%) after recrystallization from Hex/EtOAc.

Sources & evidence

ORD record
ord-745ff53df6f54de88e70b4290054ec48
Source dataset
uspto-grants-2010_12
Patent number
US07858621B2

Reaction notes

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