3-(2-Chloro-6-trifluoromethyl-pyridin-3-yl)-N-(3-ethynyl-5-fluoro-4-methanesulfonylamino-benzyl)-acrylamide → HCID 74382616, compound

HRID 2265993Notes

Reaction equation

HRID 2265993 reaction equation
Cl[C:2]1[C:7]([CH:8]=[CH:9][C:10]([NH:12][CH2:13][C:14]2[CH:19]=[C:18]([F:20])[C:17]([NH:21][S:22]([CH3:25])(=[O:24])=[O:23])=[C:16]([C:26]#[CH:27])[CH:15]=2)=[O:11])=[CH:6][CH:5]=[C:4]([C:28]([F:31])([F:30])[F:29])[N:3]=1>C(N)CCC>[CH2:2]([NH:3][C:2]1[C:7]([CH:8]=[CH:9][C:10]([NH:12][CH2:13][C:14]2[CH:19]=[C:18]([F:20])[C:17]([NH:21][S:22]([CH3:25])(=[O:23])=[O:24])=[C:16]([C:26]#[CH:27])[CH:15]=2)=[O:11])=[CH:6][CH:5]=[C:4]([C:28]([F:30])([F:31])[F:29])[N:3]=1)[CH2:7][CH2:6][CH3:5]

Participants

3

Reactant 1

HCID 743823853-(2-Chloro-6-trifluoromethyl-pyridin-3-yl)-N-(3-ethynyl-5-fluoro-4-methanesulfonylamino-benzyl)-acrylamide

Product 1

HCID 74382616HCID 74382616, compoundYield 24.6%

Reagents, catalysts & solvents 1

HCID 8007ButylamineSolvent

Procedure

3-(2-Chloro-6-trifluoromethyl-pyridin-3-yl)-N-(3-ethynyl-5-fluoro-4-methanesulfonylamino-benzyl)-acrylamide (30 mg, 0.057 mmol) was reacted with n-butylamine (500 μl) as in example 65 to give the title compound (3.6 mg, 12%) after purification by column chromatography (Hex EtOAc=1/1).

Sources & evidence

ORD record
ord-c0abbee5b61344669f08d487c0d17c4f
Source dataset
uspto-grants-2010_12
Patent number
US07858621B2

Reaction notes

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