HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(2-Chloro-6-trifluoromethyl-pyridin-3-yl)-N-(3-ethynyl-5-fluoro-4-methanesulfonylamino-benzyl)-acrylamide → HCID 74382616, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(2-Chloro-6-trifluoromethyl-pyridin-3-yl)-N-(3-ethynyl-5-fluoro-4-methanesulfonylamino-benzyl)-acrylamide | HCID 74382385 | — |
| Solvent | Butylamine | HCID 8007 | — |
| Product | HCID 74382616 | HCID 74382616 | 24.6% |
Reaction Steps
3-(2-Chloro-6-trifluoromethyl-pyridin-3-yl)-N-(3-ethynyl-5-fluoro-4-methanesulfonylamino-benzyl)-acrylamide (30 mg, 0.057 mmol) was reacted with n-butylamine (500 μl) as in example 65 to give the title compound (3.6 mg, 12%) after purification by column chromatography (Hex EtOAc=1/1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07858621B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-c0abbee5b61344669f08d487c0d17c4f |
| Source note | uspto-grants-2010_12 |