反应详情

3-(2-Chloro-6-trifluoromethyl-pyridin-3-yl)-N-(3-ethynyl-5-fluoro-4-methanesulfonylamino-benzyl)-acrylamide (30 mg, 0.057 mmol) was reacted with cyclopentylamine (500 μl) as in example 65 to give the title compound (2.5 mg, 8%) after purification by column chromatography (Hex/EtOAc=1/1).