HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopentylamine → 3-(2-Cyclopentylamino-6-trifluoromethyl-pyridin-3-yl)-N-(3-ethynyl-5-fluoro-4-methane sulfonylamino-benzyl)-acrylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopentylamine | HCID 2906 | — |
| Reactant | 3-(2-Chloro-6-trifluoromethyl-pyridin-3-yl)-N-(3-ethynyl-5-fluoro-4-methanesulfonylamino-benzyl)-acrylamide | HCID 74382385 | — |
| Product | 3-(2-Cyclopentylamino-6-trifluoromethyl-pyridin-3-yl)-N-(3-ethynyl-5-fluoro-4-methane sulfonylamino-benzyl)-acrylamide | HCID 74382617 | 8% |
Reaction Steps
3-(2-Chloro-6-trifluoromethyl-pyridin-3-yl)-N-(3-ethynyl-5-fluoro-4-methanesulfonylamino-benzyl)-acrylamide (30 mg, 0.057 mmol) was reacted with cyclopentylamine (500 μl) as in example 65 to give the title compound (2.5 mg, 8%) after purification by column chromatography (Hex/EtOAc=1/1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07858621B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-e9af8af4a7304f199534e2096cb40616 |
| Source note | uspto-grants-2010_12 |