3-(2-sec-Butoxy-6-trifluoromethyl-pyridin-3-yl)-acrylic acid → HCID 74382620, compound

HRID 2265998Notes

Reaction equation

HRID 2265998 reaction equation
Cl.[NH2:2][CH2:3][C:4]1[CH:9]=[C:8]([F:10])[C:7]([NH:11][S:12]([CH3:15])(=[O:14])=[O:13])=[C:6]([CH:16]=[CH2:17])[CH:5]=1.[CH:18]([O:22][C:23]1[C:28]([CH:29]=[CH:30][C:31](O)=[O:32])=[CH:27][CH:26]=[C:25]([C:34]([F:37])([F:36])[F:35])[N:24]=1)([CH2:20][CH3:21])[CH3:19]>>[CH:18]([O:22][C:23]1[C:28]([CH:29]=[CH:30][C:31]([NH:2][CH2:3][C:4]2[CH:9]=[C:8]([F:10])[C:7]([NH:11][S:12]([CH3:15])(=[O:14])=[O:13])=[C:6]([C:16]#[CH:17])[CH:5]=2)=[O:32])=[CH:27][CH:26]=[C:25]([C:34]([F:37])([F:35])[F:36])[N:24]=1)([CH2:20][CH3:21])[CH3:19]

Participants

3

Reactant 2

HCID 687806843-(2-sec-Butoxy-6-trifluoromethyl-pyridin-3-yl)-acrylic acidHCID 68785944HCID 68785944, compound

Product 1

HCID 74382620HCID 74382620, compoundYield 25.6%

Procedure

N-(4-Aminomethyl-2-ethenyl-6-fluoro-phenyl)-methanesulfonamide HCl salt (35 mg, 0.13 mmol) was reacted with 3-(2-sec-butoxy-6-trifluoromethyl-pyridin-3-yl)-acrylic acid (22 mg) to give the title compound (10 mg) after purification by column chromatography (Hex/EtOAc=1/1).

Sources & evidence

ORD record
ord-8db7cfc6e53941388104a8f50060aab3
Source dataset
uspto-grants-2010_12
Patent number
US07858621B2

Reaction notes

Loading…