HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Furanol, tetrahydro- → 3-[2-(Tetrahydro-furan-3-yloxy)-6-trifluoromethyl-pyridin-3-yl]-N-(3-ethynyl-5-fluoro-4-methanesulfonylamino-benzyl)-acrylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Furanol, tetrahydro- | HCID 9960 | — |
| Reactant | 3-(2-Chloro-6-trifluoromethyl-pyridin-3-yl)-N-(3-ethynyl-5-fluoro-4-methanesulfonylamino-benzyl)-acrylamide | HCID 74382385 | — |
| Product | 3-[2-(Tetrahydro-furan-3-yloxy)-6-trifluoromethyl-pyridin-3-yl]-N-(3-ethynyl-5-fluoro-4-methanesulfonylamino-benzyl)-acrylamide | HCID 74382685 | 39.6% |
Reaction Steps
3-(2-Chloro-6-trifluoromethyl-pyridin-3-yl)-N-(3-ethynyl-5-fluoro-4-methanesulfonylamino-benzyl)-acrylamide (50 mg, 0.11 mmol) and 3-hydroxytetrahydrofuran (18 μl, 0.22 mmol) was reacted as in example 72 to give the title compound (23 mg, 21%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07858621B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-678fa8fe71174a0f865208e577ad4c04 |
| Source note | uspto-grants-2010_12 |