HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Hydroxypyridine → HCID 68784033, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Hydroxypyridine | HCID 7971 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 3-(2-Chloro-6-trifluoromethyl-pyridin-3-yl)-acrylic acid | HCID 72335632 | — |
| Product | HCID 68784033 | HCID 68784033 | — |
Reaction Steps
3-Hydroxypyridine (69.1 mg) and sodiumhydride (65 mg, 1.6 mmol) were added in THF. 3-(2-Chloro-6-trifluoromethyl-pyridin-3-yl)-acrylic acid (156 mg, 0.620 mmol) was added the reaction mixture. The reaction mixture was purified to yield the title compound (15 mg) after purification by column chromatography (Hex/EtOAc=1/4).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07858621B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-1f6a2b5e13374869ba1b7ed1c19b3149 |
| Source note | uspto-grants-2010_12 |