3-Hydroxypyridine → HCID 68784033, compound

HRID 2266013Notes

Reaction equation

HRID 2266013 reaction equation
[OH:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][CH:7]=1.[H-].[Na+].Cl[C:11]1[C:16]([CH:17]=[CH:18][C:19]([OH:21])=[O:20])=[CH:15][CH:14]=[C:13]([C:22]([F:25])([F:24])[F:23])N=1.[CH2:26]1COCC1>>[N:4]1[CH:5]=[CH:6][CH:7]=[C:2]([O:1][C:11]2[CH:26]=[C:13]([C:22]([F:25])([F:24])[F:23])[CH:14]=[CH:15][C:16]=2[CH:17]=[CH:18][C:19]([OH:21])=[O:20])[CH:3]=1

Participants

5

Reactant 4

HCID 79713-HydroxypyridineHCID 8028TetrahydrofuranHCID 24758Sodium hydrideHCID 723356323-(2-Chloro-6-trifluoromethyl-pyridin-3-yl)-acrylic acid

Product 1

HCID 68784033HCID 68784033, compound

Procedure

3-Hydroxypyridine (69.1 mg) and sodiumhydride (65 mg, 1.6 mmol) were added in THF. 3-(2-Chloro-6-trifluoromethyl-pyridin-3-yl)-acrylic acid (156 mg, 0.620 mmol) was added the reaction mixture. The reaction mixture was purified to yield the title compound (15 mg) after purification by column chromatography (Hex/EtOAc=1/4).

Workup

  1. customThe reaction mixture was purified

Sources & evidence

ORD record
ord-1f6a2b5e13374869ba1b7ed1c19b3149
Source dataset
uspto-grants-2010_12
Patent number
US07858621B2

Reaction notes

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