Lithium Hydroxide → HCID 68784879, compound

HRID 2266014Notes

Reaction equation

HRID 2266014 reaction equation
C[O:2][C:3](=[O:23])[CH:4]=[CH:5][C:6]1[C:7]([S:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[N:8][C:9]([C:12]([F:15])([F:14])[F:13])=[CH:10][CH:11]=1.[Li+].[OH-]>>[C:17]1([S:16][C:7]2[C:6]([CH:5]=[CH:4][C:3]([OH:23])=[O:2])=[CH:11][CH:10]=[C:9]([C:12]([F:14])([F:15])[F:13])[N:8]=2)[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 68785533HCID 68785533, compound

Product 1

HCID 68784879HCID 68784879, compoundYield 82.1%

Procedure

3-(2-phenylthio-6-trifluoromethyl-pyridin-3-yl)-acrylic acid methyl ester (80 mg) was hydrolyzed with 1 M LiOH solution (3 mmol) at room temperature to yield the title compound (63 mg)

Sources & evidence

ORD record
ord-7a94c832be334180be0f81cf518f66da
Source dataset
uspto-grants-2010_12
Patent number
US07858621B2

Reaction notes

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