Trimethylsilylacetylene → HCID 59598308, compound

HRID 2266018Notes

Reaction equation

Cl[C:2]1[N:13]=[C:12]([C:14]([F:17])([F:16])[F:15])[CH:11]=[CH:10][C:3]=1[C:4]([N:6]([O:8][CH3:9])[CH3:7])=[O:5].[CH3:18][Si:19]([C:22]#[CH:23])([CH3:21])[CH3:20]>>[CH3:9][O:8][N:6]([CH3:7])[C:4](=[O:5])[C:3]1[CH:10]=[CH:11][C:12]([C:14]([F:17])([F:16])[F:15])=[N:13][C:2]=1[C:23]#[C:22][Si:19]([CH3:21])([CH3:20])[CH3:18]

Participants

Reactant 2

HCID 66111Trimethylsilylacetylene

HCID 59598164HCID 59598164, compound

Product 1

HCID 59598308HCID 59598308, compoundYield 60%

Procedure

2-Chloro-N-methoxy-N-methyl-6-trifluoromethyl-nicotinamide (1.2 g, 4.52 mmol) was reacted with (trimethylsilyl)acetylene (0.689 ml, 4.97 mmol) to give N-methoxy-N-methyl-6-trifluoromethyl-2-trimethylsilanylethynyl-nicotinamide (896 mg, 60%).

Sources & evidence

ORD record: ord-f28823787a9a411496bb3d069e02a9e0
Source dataset: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07858621B2

Reaction notes

Loading…