3-Methoxypropyne → HCID 86625535, compound

HRID 2266023Notes

Reaction equation

HRID 2266023 reaction equation
Cl[C:2]1[N:13]=[C:12]([C:14]([F:17])([F:16])[F:15])[CH:11]=[CH:10][C:3]=1[C:4]([N:6]([O:8][CH3:9])[CH3:7])=[O:5].[CH3:18][O:19][CH2:20][C:21]#[CH:22]>>[CH3:9][O:8][N:6]([CH3:7])[C:4](=[O:5])[C:3]1[CH:10]=[CH:11][C:12]([C:14]([F:17])([F:16])[F:15])=[N:13][C:2]=1[C:22]#[C:21][CH2:20][O:19][CH3:18]

Participants

3

Reactant 2

HCID 693933-MethoxypropyneHCID 59598164HCID 59598164, compound

Product 1

HCID 86625535HCID 86625535, compoundYield 22%

Procedure

2-Chloro-N-methoxy-N-methyl-6-trifluoromethyl-nicotinamide (1000 mg, 3.72 mmol) was reacted with 3-methoxy-propyne (0.345 ml, 4.09 mmol) to give N-methoxy-2-(3-methoxy-prop-1-ynyl)-N-methyl-6-trifluoromethyl-nicotinamide (247 mg, 22%).

Sources & evidence

ORD record
ord-8e7313c0ea594e1083177f8ede04df43
Source dataset
uspto-grants-2010_12
Patent number
US07858621B2

Reaction notes

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